Deep Brain Stimulation and Optogenetic fMRI (NIH R01 NS091236)

Deep brain stimulation (DBS) is a well-established neurosurgical therapy for multiple neurological and psychiatric disorders. Despite its rapidly growing use, the circuit mechanisms underlying the therapeutic effects of DBS are poorly understood, representing a major challenge to refinement for enhanced efficacy and reduced side effects. In DBS, an electrode is stereotactically guided to a target[…]

Chemogenetic fMRI (NIH BRAIN Initiative R01 MH111429)

Blood-oxygenation-level-dependent functional magnetic resonance imaging (BOLD fMRI) is the most widely used functional brain mapping technique in humans. While BOLD serves as an indirect proxy for neuronal activity, the cellular and molecular mechanisms underlying the BOLD signal remain poorly understood. Among various brain cells, astrocytes are central in neurovascular coupling due to their unique anatomical[…]

Stroke and Periinfarct Spreading Depolarization (AHA 15SDG23260025)

Peri-infarct spreading depolarization describes a series of propagating electrical potentials that silence brain activity, alter cerebral blood flow, induce cell swelling, and appear during the hyperacute phase of stroke. ┬áPID has been shown to accelerate stroke progression, and suppressing PID is known to reduce infarct volume. Although PID is a potential therapeutic target for stroke,[…]

Simultaneous fMRI, Electrophysiology, and Deep Brain Stimulation (NIH BRAIN Initiative R41 MH113252)

Despite tremendous research efforts, the neurophysiological basis of the fMRI signals remains unclear, limiting its data interpretation and potential clinical applications. This problem primarily stems from different neurovascular coupling among brain areas and also in various disease states. We therefore attempt to develop and test the feasibility of using an innovative MR-compatible electrode array for[…]